Prof. Dr. Ciro Gargiulo Isacco
Dr. Gargiulo Isacco attended State University in Milan, Italy where in 1996 he received his
degree (Doctorate) in Philosophy of Science where He graduated Magna Cum Laude. In 2004,
he received his degree in Traditional Oriental Medicine-Clinical Acupuncture at Traditional
Medicine Institute of Saigon. In 2009 he received his Master of Science (Clinical Medical track)
with majoring in Immunology-Immunogenetics at Manchester University, UK and in 2011 he
received his doctorate of Medical Science at University of Fribourg at Faculty of Medicine in
Fribourg, Switzerland. He was a Fellow at the UWA at the Perth Australia where he won a SIRF
international research prize. He completed a Post Graduate Certificate in Cancer Therapeutics in
2013 at Queen Mary University, Barth Institute of London in UK. Dr. Gargiulo Isacco is Board
Certified in Internal Medicine.
Dr. Gargiulo Isacco as full Professor at Tan Tao International University of Ho Chi Minh City and
Pham Chau Trinh Hoi An City Vietnam was involved in few research projects regarding the use
of stem cells, telomere measuring and anti-aging research. His mainly efforts are towards
metabolic diseases, diabetes, bone degenerative condition, and cancer, with a specific focusing to
endocrine-neuro-immunology realtion balance and nutrition centering on microbiome/microbiota.
Currently as Visiting Professor at University of Medicine Aldo Moro and he is actively
researching in the existing relation between gut microbiota, immunity, cell metabolism (ROS),
stem cells, hormones (erythropoietin, estrogen, testosterone, DHEA and GLP-1) and the
structural quality of bone tissues in peri-implant procedures.
Dr Gargiulo Isacco’s personal point of view is that the gut-microbiome condition might be a a
key factor to a general healthy regenerative capacity of the body sustaining a correct balance of
immune-neuro-endocrine systems; conversely, the dysbiosis that contribute to severe alterations
of gut micro-environment and cellular metabolism, particular type of diet rich on high content
of processed carbohydrates/sugars and carbonated drinks induce an over-expression of cellular
components such as ROS, with a consequent accumulation of intracellular and extracellular of
glucose/toxins that lead to chronic inflammatory states which eventually inhibit stem cell
activity and hormone responses heading to cell and tissue degeneration, different forms of
alterations and malignancies.
In bone metabolic research, differentiation, activation and function of osteoclasts (bone
resorbing cells), local immune cells and their interaction with osteoblast (bone forming cells) is
the main focus. Human in vitro/in-vivo metabolic models have been supposed and various
scientific questions have been addressed the role of metabolic condition in the release of metal
ions, derived from biocorosion in orthopaedic/dental metal implants on osteoclast and immune
cell activation and bone resorption, which is seen in patients with loosening of joint
replacements and dental implants.
Dr Gargiulo Isacco has and extensive experience in laboratory ground researches on human stem
cells from different sources such as adipose tissue, umbilical cord, bone marrow, placenta and
of course peripheral blood. Among the activities, he has been involved in the generation of a
innovative bio/scaffold (under patenting process) that includes a combination of beta tri-
calcium phosphate, autologous stem cells and fibrin gel to induce bone tissue augmentation.
This current project is being held together with the Odonto-Stomatology Hospital of Ho Chi
Minh City, one of the biggest institutions in Vietnam which attracts big international funds and
support. A second project (under patenting process) involves the use of autologous peripheral
blood stem cells bind to GLP-1 peptides to increase the insulin secretion in patient with diabetes
type 2; overall these experiments increased membership and attracted more than 50 students
from different classes.
Dr. Gargiulo Isacco as author has published over 25 peer international review articles on stem
cells and related topics in addition he has been invited as main guest/speaker on numerous
World International Conferences.
”THE AGING AND METABOLIC DISORDERS IN DEEP: A WAY TO UNDERSTAND BONE DEGENERATION IN IMPLANT GRAFT REJECTIONS ”
Prof. Dr. Ciro Gargiulo Isacco
Osteo-degeneration is a disorder induced by a diversity of factors and frequently
leads to the disruption of main supportive structures such as head of femur, back
vertebrae and alveolar bones in mouth. The restoration of a functional condition
involves the use of different types of graft implants calcium powder, bone derivate,
ceramics and metals and all require adequate bone volume, to deal with the kinetic
and force load. These conditions need regeneration of the supportive bones using the
advantage of the biological principles of osteogenesis, osteoinduction,
osteoconduction, bio-absorbable and bio-compatible. A number of procedures have
been developed which combine these principles with different outcomes, due to the
inner structural, mechanical and metabolic condition of the host’s bone on which
implants should be inserted and the surgical technique, and the material used to
perform the procedure. However among all those the most important and the most
disregarded is the aging process associated with predominant metabolic disease of the
patient who may reveal systemic functional decay which involves hormonal, immune
functionality with a gradual and steady decline of osteo-activity that can also
eventually affect the positive outcomes of bone reconstruction and implant success.
In this review we analyze the biological and physiological reasons involved in the
bone tissue break-down, such as the influences from gut microbiome balance and
consequent metabolic, endocrine, immune dysfunctions, the surgery procedures and
the quality of the material used.
Therefore the decline of bone structure, integrity and density should be corrected by
using a wider clinical regenerative approach with the perspective from a bioendocrine, metabolic and immune know-how.
The capacity and the size of
regenerated bone has to support the kinetic forces transmitted by the implants,
whether inserted in limbs, back or in mouth and should respond to the different
perquisites of each individual condition.